Current Opinion on the Use of c-Fos in Neuroscience

For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at central nervous system level have been extensively studied scientific community through numerous techniques animal models. example, one of these is use immediate expression genes, which a useful, accessible, reliable method for observing quantifying cell activation. It has shown both c-fos gene its protein c-Fos rapid activation after stimulus, with length time they remain active depending on type stimulus structure studied. Fos requires participation other genes (such as c-jun) (during hetero-dimer forming). dimerizes c-Jun to form factor AP-1, promotes transcription various genes. The production removal part cellular homeostasis, but overexpression results in increased proliferation. Although used marker activity since 1990s, molecular mechanism participates regulation this still unknown because not specific neurons or glial cells. reasons, work objective gathering information about neuroscience.